EchoNext

Cloud software that analyzes standard 3T diffusion MRI, with no radiotracer, to help distinguish multiple system atrophy (parkinsonian variant) and progressive supranuclear palsy from Parkinson's disease. Authorization created a new device category and rested on a prospective, NIH-supported study at 21 Parkinson Study Group centers. It is an adjunct only: it does not exclude other causes of parkinsonism, and management should not rest on its output alone.

A once-daily oral tablet for adults with Parkinson's disease, with or without levodopa; unlike existing agonists, which act mainly on D2/D3 receptors, it selectively activates D1/D5. In TEMPO-3, as adjunct to levodopa in patients with motor fluctuations, daily 'on' time without troublesome dyskinesia rose by 1.7 hours versus 0.6 hours with placebo. Warnings include orthostatic hypotension, hallucinations, dyskinesia and impulse-control urges.

A 10-day sensor for people with diabetes aged 2 and older that measures ketones and glucose in interstitial fluid every minute and sends readings, trends and rising-level alerts to a smartphone. Across six clinical studies in more than 600 participants it tracked clinically meaningful ketone differences, including elevated ketones before the onset of diabetic ketoacidosis. Ketone readings should be interpreted with glucose values and symptoms, and do not replace confirmatory testing before treatment decisions.